Lion's Mane Mushroom Research

Teelixir's evidence-based guide to Hericium erinaceus — the only mushroom shown to stimulate Nerve Growth Factor (NGF) in human tissue. Our research library draws on 571+ published studies, including 28 human clinical trials, to give you an honest picture of what lion's mane can and cannot do.

Start here: Lion's Mane Benefits — What 571 Studies Show · Dosage Guide · Side Effects & Safety · Buying Guide for Australia

By health goal: ADHD & Focus · Anxiety · Brain Fog · Gut Health · Depression & Mood · Immune System · Stress & Cortisol

Compare: vs Ashwagandha · vs Cordyceps · vs Reishi · vs Chaga · vs Turkey Tail · Fruiting Body vs Mycelium

How to use: Powder vs Extract vs Capsules · When to Take · Beginner's Guide · Recipes · Lion's Mane Tea

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Lion's Mane

Lion's Mane for Stress: What the Research Shows About The Indirect Pathway
We review the human RCTs and preclinical evidence on lion's mane mushroom and stress. Covers the NGF mechanism, the cortisol question, and when lion's mane is the right choice. Honest, evidence-based analysis with PubMed citations.
Lion's Mane and Antidepressants: The Clinical Evidence
Can lion's mane be taken with antidepressants? We examine 7 human trials and the Neurotrophin Gap Effect.
Lion's Mane for Depression & Mood: The Evidence Review
A research-grounded review of lion's mane mushroom and its preliminary evidence for mood support — including the neurotrophic mechanism, human trial data, honest limitations, and safe use guidance.