Lion's Mane Mushroom Research

Teelixir's evidence-based guide to Hericium erinaceus — the only mushroom shown to stimulate Nerve Growth Factor (NGF) in human tissue. Our research library draws on 571+ published studies, including 28 human clinical trials, to give you an honest picture of what lion's mane can and cannot do.

Start here: Lion's Mane Benefits — What 571 Studies Show · Dosage Guide · Side Effects & Safety · Buying Guide for Australia

By health goal: ADHD & Focus · Anxiety · Brain Fog · Gut Health · Depression & Mood · Immune System · Stress & Cortisol

Compare: vs Ashwagandha · vs Cordyceps · vs Reishi · vs Chaga · vs Turkey Tail · Fruiting Body vs Mycelium

How to use: Powder vs Extract vs Capsules · When to Take · Beginner's Guide · Recipes · Lion's Mane Tea

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Lion's Mane

Lion's Mane for Anxiety: What the Research Actually Shows
By Peter Orpen — Co-Owner & Formulator, Teelixir Published: 27 March 2026 Updated: 27 March 2026 PRELIMINARY Evidence Grade — Anxiety & Mood 571 LM Published Studies 3 Human RCTs (Anxiety/Mood) 1 Animal Study (Sleep-Anxiety) 2 Systematic Reviews Evidence sourced...
Lion's Mane and Antidepressants: The Clinical Evidence
Can lion's mane be taken with antidepressants? We examine 7 human trials and the Neurotrophin Gap Effect.
Lion's Mane for Depression & Mood: The Evidence Review
A research-grounded review of lion's mane mushroom and its preliminary evidence for mood support — including the neurotrophic mechanism, human trial data, honest limitations, and safe use guidance.